{
  "_id": "6a103b04acfb0bcc41c9b628",
  "Package": "PKPDsim",
  "Type": "Package",
  "Title": "Tools for Performing Pharmacokinetic-Pharmacodynamic Simulations",
  "Version": "1.5.0",
  "Date": "2025-07-08",
  "Authors@R": "c(\nperson(\"Ron\", \"Keizer\", email = \"ron@insight-rx.com\", role = c(\"aut\", \"cre\")),\nperson(\"Jasmine\", \"Hughes\", email = \"jasmine@insight-rx.com\", role = \"aut\"),\nperson(\"Dominic\", \"Tong\", email = \"dominic@insight-rx.com\", role = \"aut\"),\nperson(\"Kara\", \"Woo\", email = \"kara@insight-rx.com\", role = c(\"aut\")),\nperson(\"Jordan\", \"Brooks\", email = \"jordan.brooks@insight-rx.com\", role = \"aut\"),\nperson(\"InsightRX\", role = c(\"cph\", \"fnd\")))",
  "Description": "Simulate dose regimens for pharmacokinetic-pharmacodynamic\n(PK-PD) models described by differential equation (DE) systems.\nSimulation using ADVAN-style analytical equations is also\nsupported (Abuhelwa et al. (2015)\n<doi:10.1016/j.vascn.2015.03.004>).",
  "License": "MIT + file LICENSE",
  "URL": "https://github.com/InsightRX/PKPDsim,\nhttps://insightrx.github.io/PKPDsim/",
  "Language": "en-US",
  "LazyData": "TRUE",
  "Roxygen": "list(markdown = TRUE)",
  "RoxygenNote": "7.3.3",
  "Config/testthat/edition": "3",
  "Config/Needs/website": "tidyverse, nlmixr2",
  "Encoding": "UTF-8",
  "VignetteBuilder": "knitr",
  "Config/pak/sysreqs": "libicu-dev",
  "Repository": "https://insightrx.r-universe.dev",
  "Date/Publication": "2026-05-11 18:00:49 UTC",
  "RemoteUrl": "https://github.com/insightrx/pkpdsim",
  "RemoteRef": "HEAD",
  "RemoteSha": "6f96c3ef5e8d09e99aec7ec01dd456a65fd060c3",
  "NeedsCompilation": "yes",
  "Packaged": {
    "Date": "2026-05-11 19:25:16 UTC",
    "User": "root"
  },
  "Author": "Ron Keizer [aut, cre],\nJasmine Hughes [aut],\nDominic Tong [aut],\nKara Woo [aut],\nJordan Brooks [aut],\nInsightRX [cph, fnd]",
  "Maintainer": "Ron Keizer <ron@insight-rx.com>",
  "MD5sum": "3254282007e01e2294f64fa34992ee0f",
  "_user": "insightrx",
  "_type": "src",
  "_file": "PKPDsim_1.5.0.tar.gz",
  "_fileid": "c3dff76409725beacd5d89b72d621233a1e92ebc25fd98e303144ec8bd656e34",
  "_filesize": 441257,
  "_sha256": "c3dff76409725beacd5d89b72d621233a1e92ebc25fd98e303144ec8bd656e34",
  "_created": "2026-05-11T19:25:16.000Z",
  "_published": "2026-05-22T11:16:20.830Z",
  "_distro": "noble",
  "_jobs": [
    {
      "job": 77368600881,
      "time": 271,
      "config": "linux-devel-arm64",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "6927960206"
    },
    {
      "job": 77368600762,
      "time": 299,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "6927969624"
    },
    {
      "job": 77368600889,
      "time": 245,
      "config": "linux-release-arm64",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "6927950566"
    },
    {
      "job": 77368600731,
      "time": 264,
      "config": "linux-release-x86_64",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "6927957461"
    },
    {
      "job": 77368600922,
      "time": 287,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "6927952919"
    },
    {
      "job": 77368600861,
      "time": 602,
      "config": "macos-oldrel-x86_64",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "6928056017"
    },
    {
      "job": 77368600997,
      "time": 301,
      "config": "macos-release-arm64",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "6927956204"
    },
    {
      "job": 77368601059,
      "time": 318,
      "config": "macos-release-x86_64",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "6927972099"
    },
    {
      "job": 77368600536,
      "time": 341,
      "config": "source",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "6927867596"
    },
    {
      "job": 77368600453,
      "time": 162,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7159182564"
    },
    {
      "job": 77368600816,
      "time": 378,
      "config": "windows-devel",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "6927996739"
    },
    {
      "job": 77368600802,
      "time": 386,
      "config": "windows-oldrel",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "6928000018"
    },
    {
      "job": 77368600769,
      "time": 263,
      "config": "windows-release",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "6927957576"
    }
  ],
  "_buildurl": "https://github.com/r-universe/insightrx/actions/runs/25691947390",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_upstream": "https://github.com/insightrx/pkpdsim",
  "_commit": {
    "id": "6f96c3ef5e8d09e99aec7ec01dd456a65fd060c3",
    "author": "Jasmine Hughes <43552465+jasmineirx@users.noreply.github.com>",
    "committer": "GitHub <noreply@github.com>",
    "message": "Merge pull request #137 from InsightRX/RXR-3133\n\nRXR-3133: add flexibility in how we determine infusion",
    "time": 1778522449
  },
  "_maintainer": {
    "name": "Ron Keizer",
    "email": "ron@insight-rx.com",
    "login": "roninsightrx",
    "uuid": 15008273
  },
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 4.0.0",
      "role": "Depends"
    },
    {
      "package": "BH",
      "role": "LinkingTo"
    },
    {
      "package": "Rcpp",
      "version": ">= 1.0.13",
      "role": "LinkingTo"
    },
    {
      "package": "Rcpp",
      "version": ">= 1.0.13",
      "role": "Imports"
    },
    {
      "package": "BH",
      "role": "Imports"
    },
    {
      "package": "data.table",
      "role": "Imports"
    },
    {
      "package": "stringr",
      "role": "Imports"
    },
    {
      "package": "MASS",
      "role": "Imports"
    },
    {
      "package": "randtoolbox",
      "role": "Imports"
    },
    {
      "package": "jsonlite",
      "role": "Imports"
    },
    {
      "package": "stats",
      "role": "Imports"
    },
    {
      "package": "parallel",
      "role": "Imports"
    },
    {
      "package": "magrittr",
      "role": "Imports"
    },
    {
      "package": "httr",
      "role": "Suggests"
    },
    {
      "package": "testthat",
      "version": ">= 3.0.0",
      "role": "Suggests"
    },
    {
      "package": "knitr",
      "role": "Suggests"
    },
    {
      "package": "rmarkdown",
      "role": "Suggests"
    }
  ],
  "_owner": "insightrx",
  "_selfowned": true,
  "_usedby": 0,
  "_updates": [
    {
      "week": "2025-19",
      "n": 1
    },
    {
      "week": "2025-20",
      "n": 1
    },
    {
      "week": "2025-23",
      "n": 1
    },
    {
      "week": "2025-24",
      "n": 1
    },
    {
      "week": "2025-26",
      "n": 1
    },
    {
      "week": "2025-28",
      "n": 1
    },
    {
      "week": "2025-33",
      "n": 1
    },
    {
      "week": "2025-34",
      "n": 1
    },
    {
      "week": "2025-35",
      "n": 1
    },
    {
      "week": "2025-36",
      "n": 1
    },
    {
      "week": "2025-48",
      "n": 1
    },
    {
      "week": "2026-04",
      "n": 1
    },
    {
      "week": "2026-06",
      "n": 1
    },
    {
      "week": "2026-08",
      "n": 1
    },
    {
      "week": "2026-12",
      "n": 1
    },
    {
      "week": "2026-13",
      "n": 1
    },
    {
      "week": "2026-20",
      "n": 1
    }
  ],
  "_tags": [
    {
      "name": "v1.73",
      "date": "2025-06-25"
    },
    {
      "name": "v1.74",
      "date": "2025-06-25"
    },
    {
      "name": "v1.75",
      "date": "2025-08-22"
    },
    {
      "name": "v1.76",
      "date": "2025-08-26"
    },
    {
      "name": "v1.77",
      "date": "2025-09-05"
    },
    {
      "name": "v1.78",
      "date": "2025-09-05"
    },
    {
      "name": "v1.79",
      "date": "2025-09-05"
    },
    {
      "name": "v1.80",
      "date": "2025-11-24"
    },
    {
      "name": "v1.81",
      "date": "2025-11-24"
    },
    {
      "name": "v1.82",
      "date": "2026-02-02"
    },
    {
      "name": "v1.83",
      "date": "2026-02-18"
    },
    {
      "name": "v1.84",
      "date": "2026-03-27"
    },
    {
      "name": "v1.85",
      "date": "2026-03-27"
    }
  ],
  "_topics": [
    "ode",
    "pharmacodynamics",
    "pharmacokinetics",
    "pharmacometrics",
    "cpp"
  ],
  "_stars": 49,
  "_contributors": [
    {
      "user": "roninsightrx",
      "count": 484,
      "uuid": 15008273
    },
    {
      "user": "ronkeizer",
      "count": 437,
      "uuid": 243793
    },
    {
      "user": "karawoo",
      "count": 175,
      "uuid": 4452678
    },
    {
      "user": "jasmineirx",
      "count": 164,
      "uuid": 43552465
    },
    {
      "user": "vikrammatange",
      "count": 45,
      "uuid": 31862085
    },
    {
      "user": "jordanbrooks33",
      "count": 16,
      "uuid": 129786148
    },
    {
      "user": "dominic-irx",
      "count": 9,
      "uuid": 59584945
    },
    {
      "user": "insightrx-ci",
      "count": 8,
      "uuid": 33671449
    },
    {
      "user": "mccarthy-m-g",
      "count": 6,
      "uuid": 51542091
    },
    {
      "user": "dpastoor",
      "count": 4,
      "uuid": 3196313
    },
    {
      "user": "willfox",
      "count": 3,
      "uuid": 5420571
    },
    {
      "user": "sermetpekin",
      "count": 2,
      "uuid": 96650846
    },
    {
      "user": "benjaminrich",
      "count": 1,
      "uuid": 17572252
    },
    {
      "user": "shanmdphd",
      "count": 1,
      "uuid": 6946821
    }
  ],
  "_userbio": {
    "uuid": 14945763,
    "type": "organization",
    "name": "InsightRX",
    "description": "Precision dosing and clinical analytics"
  },
  "_downloads": {
    "count": 825,
    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/PKPDsim"
  },
  "_devurl": "https://github.com/insightrx/pkpdsim",
  "_pkgdown": "https://insightrx.github.io/PKPDsim/",
  "_searchresults": 101,
  "_rbuild": "4.6.0",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/NEWS.html",
    "extra/NEWS.txt",
    "extra/PKPDsim.html",
    "extra/readme.html",
    "extra/readme.md",
    "manual.pdf"
  ],
  "_homeurl": "https://github.com/insightrx/pkpdsim",
  "_realowner": "insightrx",
  "_cranurl": true,
  "_releases": [
    {
      "version": "1.1.0",
      "date": "2022-01-19"
    },
    {
      "version": "1.1.1",
      "date": "2022-04-01"
    },
    {
      "version": "1.3.0",
      "date": "2023-03-02"
    },
    {
      "version": "1.4.0",
      "date": "2024-08-19"
    },
    {
      "version": "1.4.1",
      "date": "2025-04-17"
    }
  ],
  "_exports": [
    "add_quotes",
    "add_ruv",
    "add_ruv_to_quantile",
    "adherence_binomial",
    "adherence_markov",
    "advan",
    "advan_create_data",
    "advan_parse_output",
    "advan_process_infusion_doses",
    "apply_duration_scale",
    "available_default_literature_models",
    "calc_auc_analytic",
    "calc_ss_analytic",
    "calculate_parameters",
    "compile_sim_cpp",
    "covariate_last_obs_only",
    "covariates_table_to_list",
    "cv_to_omega",
    "detect_ode_syntax",
    "f_cov",
    "get_model_auc_compartment",
    "get_model_covariates",
    "get_model_fixed_parameters",
    "get_model_iov",
    "get_model_linearity",
    "get_model_parameters",
    "get_model_structure",
    "get_ode_model_size",
    "get_parameters_from_code",
    "get_var_y",
    "ifelse0",
    "install_default_literature_model",
    "is_positive_definite",
    "join_cov_and_par",
    "join_regimen",
    "merge_regimen",
    "model_from_api",
    "model_library",
    "mvrnorm2",
    "na_locf",
    "new_adherence",
    "new_covariate",
    "new_covariate_model",
    "new_ode_model",
    "new_regimen",
    "nlmixr_parse_parameters",
    "nm_to_regimen",
    "pkpdsim_to_nlmixr",
    "pop_regimen",
    "print_list",
    "read_model_json",
    "regimen_to_nm",
    "reparametrize",
    "search_replace_in_file",
    "shift_regimen",
    "sim",
    "sim_core",
    "sim_ode",
    "sim_ode_shiny",
    "table_to_list",
    "test_model",
    "test_pointer",
    "translate_ode",
    "triangle_to_full"
  ],
  "_datasets": [
    {
      "name": "pkdata",
      "title": "PK dataset",
      "object": "pkdata",
      "class": [
        "data.frame"
      ],
      "fields": [
        "ID",
        "TIME",
        "DV",
        "AMT",
        "CMT",
        "MDV",
        "EVID",
        "WT",
        "CRCL",
        "AGE",
        "SEX",
        "CENT"
      ],
      "rows": 624,
      "table": true,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "add_quotes",
      "title": "Put vector values in quotes",
      "topics": [
        "add_quotes"
      ]
    },
    {
      "page": "add_ruv",
      "title": "Add residual variability to the dependent variable",
      "topics": [
        "add_ruv"
      ]
    },
    {
      "page": "add_ruv_to_quantile",
      "title": "Calculate the increase in a specific quantile for a distribution on y when residual variability is added",
      "topics": [
        "add_ruv_to_quantile"
      ]
    },
    {
      "page": "adherence_binomial",
      "title": "Binomial adherence",
      "topics": [
        "adherence_binomial"
      ]
    },
    {
      "page": "adherence_markov",
      "title": "Markov adherence model",
      "topics": [
        "adherence_markov"
      ]
    },
    {
      "page": "advan",
      "title": "ADVAN-style functions to calculate linear PK systems",
      "topics": [
        "advan"
      ]
    },
    {
      "page": "advan_create_data",
      "title": "Create ADVAN-style dataset",
      "topics": [
        "advan_create_data"
      ]
    },
    {
      "page": "advan_parse_output",
      "title": "Internal function to parse the raw output from ADVAN-style functions",
      "topics": [
        "advan_parse_output"
      ]
    },
    {
      "page": "advan_process_infusion_doses",
      "title": "Add column RATEALL to ADVAN-style dataset to handle infusions",
      "topics": [
        "advan_process_infusion_doses"
      ]
    },
    {
      "page": "apply_duration_scale",
      "title": "Apply infusion duration scale to a regimen",
      "topics": [
        "apply_duration_scale"
      ]
    },
    {
      "page": "available_default_literature_models",
      "title": "See models from the literature available for installation",
      "topics": [
        "available_default_literature_models"
      ]
    },
    {
      "page": "calc_auc_analytic",
      "title": "Convenience function to calculate the AUC based on PK model parameters at any given moment, for linear iv models.",
      "topics": [
        "calc_auc_analytic"
      ]
    },
    {
      "page": "calc_dydP",
      "title": "Calculate derivative",
      "topics": [
        "calc_dydP"
      ]
    },
    {
      "page": "calc_ss_analytic",
      "title": "Returns the state of a linear PK system at steady state (trough) using analytics equations (so for linear PK systems only).",
      "topics": [
        "calc_ss_analytic"
      ]
    },
    {
      "page": "calculate_parameters",
      "title": "Calculate model-specific variables using a dummy call to sim_ode()",
      "topics": [
        "calculate_parameters"
      ]
    },
    {
      "page": "check_obs_input",
      "title": "Checks obs input for valid combinations of cmt, var, scale",
      "topics": [
        "check_obs_input"
      ]
    },
    {
      "page": "compile_sim_cpp",
      "title": "Compile ODE model to c++ function",
      "topics": [
        "compile_sim_cpp"
      ]
    },
    {
      "page": "covariate_last_obs_only",
      "title": "Use only last observed covariate values",
      "topics": [
        "covariate_last_obs_only"
      ]
    },
    {
      "page": "covariates_table_to_list",
      "title": "Convert covariate table specified as data.frame",
      "topics": [
        "covariates_table_to_list"
      ]
    },
    {
      "page": "cv_to_omega",
      "title": "Create lower-diagonal omega matrix from CV for parameter estimates",
      "topics": [
        "cv_to_omega"
      ]
    },
    {
      "page": "detect_ode_syntax",
      "title": "Auto-detect the syntax for the ODE code",
      "topics": [
        "detect_ode_syntax"
      ]
    },
    {
      "page": "f_cov",
      "title": "covariate function builder",
      "topics": [
        "f_cov"
      ]
    },
    {
      "page": "get_fixed_parameters",
      "title": "Get fixed parameters from model definition.",
      "topics": [
        "get_fixed_parameters"
      ]
    },
    {
      "page": "get_model_info",
      "title": "Functions for getting information about a model",
      "topics": [
        "get_model_auc_compartment",
        "get_model_covariates",
        "get_model_fixed_parameters",
        "get_model_info",
        "get_model_iov",
        "get_model_linearity",
        "get_model_parameters",
        "get_model_structure"
      ]
    },
    {
      "page": "get_ode_model_size",
      "title": "Get the number of states in the ODE from the code code C++ code for model",
      "topics": [
        "get_ode_model_size"
      ]
    },
    {
      "page": "get_parameters_from_code",
      "title": "Get model parameters from code",
      "topics": [
        "get_parameters_from_code"
      ]
    },
    {
      "page": "get_var_y",
      "title": "Get expected variance/sd/ci of dependent variable based on PKPDsim model, parameters, and regimen",
      "topics": [
        "get_var_y"
      ]
    },
    {
      "page": "ifelse0",
      "title": "ifelse function but then based on whether value is NULL or not",
      "topics": [
        "ifelse0"
      ]
    },
    {
      "page": "install_default_literature_model",
      "title": "Install default literature model",
      "topics": [
        "install_default_literature_model"
      ]
    },
    {
      "page": "is_bolus_or_oral",
      "title": "Is regimen type oral or bolus? (i.e., treat t_inf as zero)",
      "topics": [
        "is_bolus_or_oral"
      ]
    },
    {
      "page": "is_positive_definite",
      "title": "Is matrix positive definite",
      "topics": [
        "is_positive_definite"
      ]
    },
    {
      "page": "join_cov_and_par",
      "title": "Combines covariates and parameters into a single list, useful for reparametrization of the model.",
      "topics": [
        "join_cov_and_par"
      ]
    },
    {
      "page": "join_regimen",
      "title": "Join two dosing regimens",
      "topics": [
        "join_regimen"
      ]
    },
    {
      "page": "lower_triangle_mat_size",
      "title": "Size of the lower triangle of the matrix",
      "topics": [
        "lower_triangle_mat_size"
      ]
    },
    {
      "page": "merge_regimen",
      "title": "Merge two regimens together.",
      "topics": [
        "merge_regimen"
      ]
    },
    {
      "page": "model_from_api",
      "title": "Load model definition from API, and compile to R library",
      "topics": [
        "model_from_api"
      ]
    },
    {
      "page": "model_library",
      "title": "Model library",
      "topics": [
        "model_library"
      ]
    },
    {
      "page": "mvrnorm2",
      "title": "More powerful multivariate normal sampling function",
      "topics": [
        "mvrnorm2"
      ]
    },
    {
      "page": "na_locf",
      "title": "Fill in NAs with the previous non-missing value",
      "topics": [
        "na_locf"
      ]
    },
    {
      "page": "new_adherence",
      "title": "Probabilistically model adherence",
      "topics": [
        "new_adherence"
      ]
    },
    {
      "page": "new_covariate",
      "title": "New covariate",
      "topics": [
        "new_covariate"
      ]
    },
    {
      "page": "new_covariate_model",
      "title": "covariate model function",
      "topics": [
        "new_covariate_model"
      ]
    },
    {
      "page": "new_ode_model",
      "title": "Create new ODE model",
      "topics": [
        "new_ode_model"
      ]
    },
    {
      "page": "new_regimen",
      "title": "Dose regimen for sim_ode",
      "topics": [
        "new_regimen"
      ]
    },
    {
      "page": "nlmixr_parse_parameters",
      "title": "Function to parse parameters for a model into a structure used by nlmixr",
      "topics": [
        "nlmixr_parse_parameters"
      ]
    },
    {
      "page": "nm_to_regimen",
      "title": "Create a regimen from NONMEM data",
      "topics": [
        "nm_to_regimen"
      ]
    },
    {
      "page": "parse_lagtime",
      "title": "Parse lagtime specified to main sim() function",
      "topics": [
        "parse_lagtime"
      ]
    },
    {
      "page": "pkdata",
      "title": "PK dataset",
      "topics": [
        "pkdata"
      ]
    },
    {
      "page": "pkpdsim_to_nlmixr",
      "title": "Convert a model generated with PKPDsim to an object for nlmixr",
      "topics": [
        "pkpdsim_to_nlmixr"
      ]
    },
    {
      "page": "pop_regimen",
      "title": "Remove n doses (from tail) of PKPDsim regimen",
      "topics": [
        "pop_regimen"
      ]
    },
    {
      "page": "print_list",
      "title": "Return a list in R syntax",
      "topics": [
        "print_list"
      ]
    },
    {
      "page": "read_model_json",
      "title": "Read model definition from JSON",
      "topics": [
        "read_model_json"
      ]
    },
    {
      "page": "regimen_to_nm",
      "title": "Convert PKPDsim regimen to NONMEM table (doses only)",
      "topics": [
        "regimen_to_nm"
      ]
    },
    {
      "page": "reparametrize",
      "title": "Reparametrize model parameters using a reparametrization defined within the model.",
      "topics": [
        "reparametrize"
      ]
    },
    {
      "page": "search_replace_in_file",
      "title": "Find string and replace in file",
      "topics": [
        "search_replace_in_file"
      ]
    },
    {
      "page": "shift_regimen",
      "title": "Remove n doses (from start) of PKPDsim regimen",
      "topics": [
        "shift_regimen"
      ]
    },
    {
      "page": "sim",
      "title": "Simulate ODE or analytical equation",
      "topics": [
        "sim"
      ]
    },
    {
      "page": "sim_core",
      "title": "Only core function of the simulation function, always just returns observations. Mostly useful for estimations / optimal design. Has no checks (for speed)!",
      "topics": [
        "sim_core"
      ]
    },
    {
      "page": "sim_ode",
      "title": "Deprecated function, renamed to 'sim()'",
      "topics": [
        "sim_ode"
      ]
    },
    {
      "page": "sim_ode_shiny",
      "title": "Simulate ODE and create a Shiny app",
      "topics": [
        "sim_ode_shiny"
      ]
    },
    {
      "page": "table_to_list",
      "title": "Convert a table to a list",
      "topics": [
        "table_to_list"
      ]
    },
    {
      "page": "test_model",
      "title": "Test a model",
      "topics": [
        "test_model"
      ]
    },
    {
      "page": "test_pointer",
      "title": "Test if model still in memory",
      "topics": [
        "test_pointer"
      ]
    },
    {
      "page": "translate_ode",
      "title": "Translate a model from/to various PKPD simulators",
      "topics": [
        "translate_ode"
      ]
    },
    {
      "page": "triangle_to_full",
      "title": "Convert triangle omega matrix to full omega matrix",
      "topics": [
        "triangle_to_full"
      ]
    }
  ],
  "_readme": "https://github.com/insightrx/pkpdsim/raw/HEAD/README.md",
  "_rundeps": [
    "BH",
    "cli",
    "data.table",
    "glue",
    "jsonlite",
    "lifecycle",
    "magrittr",
    "MASS",
    "randtoolbox",
    "Rcpp",
    "rlang",
    "rngWELL",
    "stringi",
    "stringr",
    "vctrs"
  ],
  "_sysdeps": [
    {
      "shlib": "libstdc++",
      "package": "libstdc++6",
      "source": "gcc",
      "version": "14.2.0-4ubuntu2~24.04.1",
      "name": "c++",
      "homepage": "http://gcc.gnu.org/",
      "description": "GNU Standard C++ Library v3"
    }
  ],
  "_vignettes": [
    {
      "source": "example-absorption-models.Rmd",
      "filename": "example-absorption-models.html",
      "title": "Absorption models",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Absorption with lag time",
        "Absorption transit compartments"
      ],
      "created": "2022-06-15 20:23:23",
      "modified": "2024-10-25 16:28:19",
      "commits": 3
    },
    {
      "source": "covariates.Rmd",
      "filename": "covariates.html",
      "title": "Covariates",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Covariates",
        "Time-varying covariates",
        "Covariates for multiple patients"
      ],
      "created": "2022-06-15 20:23:23",
      "modified": "2024-07-31 19:44:06",
      "commits": 2
    },
    {
      "source": "export-model.Rmd",
      "filename": "export-model.html",
      "title": "Export model",
      "engine": "knitr::rmarkdown",
      "headings": [],
      "created": "2022-06-15 20:23:23",
      "modified": "2024-10-25 16:28:19",
      "commits": 2
    },
    {
      "source": "model.Rmd",
      "filename": "model.html",
      "title": "Model",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Introduction",
        "Model from library",
        "Custom model from code",
        "More custom model options",
        "Dosing / bioavailability",
        "Observations",
        "Custom model from file"
      ],
      "created": "2022-06-15 20:23:23",
      "modified": "2024-10-25 16:28:19",
      "commits": 4
    },
    {
      "source": "output.Rmd",
      "filename": "output.html",
      "title": "Output",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Multiple observation types",
        "Parameters, variables, and covariates"
      ],
      "created": "2022-06-15 20:23:23",
      "modified": "2024-10-25 16:28:19",
      "commits": 2
    },
    {
      "source": "parameters.Rmd",
      "filename": "parameters.html",
      "title": "Parameters",
      "engine": "knitr::rmarkdown",
      "headings": [],
      "created": "2022-06-15 20:23:23",
      "modified": "2022-06-15 20:23:23",
      "commits": 1
    },
    {
      "source": "regimen.Rmd",
      "filename": "regimen.html",
      "title": "Regimen",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Steady state"
      ],
      "created": "2022-06-15 20:23:23",
      "modified": "2024-10-25 16:28:19",
      "commits": 4
    },
    {
      "source": "simulation.Rmd",
      "filename": "simulation.html",
      "title": "Simulation",
      "engine": "knitr::rmarkdown",
      "headings": [],
      "created": "2022-06-15 20:23:23",
      "modified": "2022-06-15 20:23:23",
      "commits": 1
    },
    {
      "source": "speed.Rmd",
      "filename": "speed.html",
      "title": "Speed",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Comparison with other packages"
      ],
      "created": "2022-06-15 20:23:23",
      "modified": "2024-10-25 16:28:19",
      "commits": 2
    }
  ],
  "_score": 9.692122241271612,
  "_indexed": true,
  "_nocasepkg": "pkpdsim",
  "_universes": [
    "insightrx",
    "roninsightrx"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "1.5.0",
      "date": "2026-05-11T19:28:22.000Z",
      "distro": "noble",
      "arch": "aarch64",
      "commit": "6f96c3ef5e8d09e99aec7ec01dd456a65fd060c3",
      "fileid": "7b0f80c4e8af3ccc36e0d36af53200a9aef6d95231b27a98fbfad444724f8f95",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/insightrx/actions/runs/25691947390"
    },
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "1.5.0",
      "date": "2026-05-11T19:28:46.000Z",
      "distro": "noble",
      "arch": "x86_64",
      "commit": "6f96c3ef5e8d09e99aec7ec01dd456a65fd060c3",
      "fileid": "a262e6b6056c88cff2f2d7b85656224d676e3579be884e5e477809f83089ae25",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/insightrx/actions/runs/25691947390"
    },
    {
      "r": "4.6.0",
      "os": "linux",
      "version": "1.5.0",
      "date": "2026-05-11T19:28:00.000Z",
      "distro": "noble",
      "arch": "aarch64",
      "commit": "6f96c3ef5e8d09e99aec7ec01dd456a65fd060c3",
      "fileid": "7ac40f021856c414f3957ec548a97e169180dddda4bc8ac2d5cf97ea55fe01df",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/insightrx/actions/runs/25691947390"
    },
    {
      "r": "4.6.0",
      "os": "linux",
      "version": "1.5.0",
      "date": "2026-05-11T19:28:41.000Z",
      "distro": "noble",
      "arch": "x86_64",
      "commit": "6f96c3ef5e8d09e99aec7ec01dd456a65fd060c3",
      "fileid": "e416ade148d40e5239e6a2b88ad3bd0f0672b6ec419042c386e37929cb1f3e0b",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/insightrx/actions/runs/25691947390"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "1.5.0",
      "date": "2026-05-11T19:28:19.000Z",
      "arch": "aarch64",
      "commit": "6f96c3ef5e8d09e99aec7ec01dd456a65fd060c3",
      "fileid": "b42fac8d8767a76638098994927655189a093d22a0191524b91d5cc37a2f3605",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/insightrx/actions/runs/25691947390"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "1.5.0",
      "date": "2026-05-11T19:31:28.000Z",
      "arch": "x86_64",
      "commit": "6f96c3ef5e8d09e99aec7ec01dd456a65fd060c3",
      "fileid": "be3296f27193c58b5ae50cd06cd701624414514055cc738dbc2f6e75db909280",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/insightrx/actions/runs/25691947390"
    },
    {
      "r": "4.6.0",
      "os": "mac",
      "version": "1.5.0",
      "date": "2026-05-11T19:28:03.000Z",
      "arch": "aarch64",
      "commit": "6f96c3ef5e8d09e99aec7ec01dd456a65fd060c3",
      "fileid": "6ffc588157539713bcd5875be985791e77d1a8bafbce0ea6d462c9d730836765",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/insightrx/actions/runs/25691947390"
    },
    {
      "r": "4.6.0",
      "os": "mac",
      "version": "1.5.0",
      "date": "2026-05-11T19:28:12.000Z",
      "arch": "x86_64",
      "commit": "6f96c3ef5e8d09e99aec7ec01dd456a65fd060c3",
      "fileid": "98882e8f98150eb260338518e62adc2346f6a8b80930903af57a4e52da30df25",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/insightrx/actions/runs/25691947390"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "1.5.0",
      "date": "2026-05-11T19:27:58.000Z",
      "arch": "x86_64",
      "commit": "6f96c3ef5e8d09e99aec7ec01dd456a65fd060c3",
      "fileid": "7f33acd4ec03578ecf5eac96a384ce37f84e35b43942814251f042067a793326",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/insightrx/actions/runs/25691947390"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "1.5.0",
      "date": "2026-05-11T19:27:50.000Z",
      "arch": "x86_64",
      "commit": "6f96c3ef5e8d09e99aec7ec01dd456a65fd060c3",
      "fileid": "dc3b4ff60b0511e3918f97728886d4b6c5bfb43fb46b7214abf1da29088a93d0",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/insightrx/actions/runs/25691947390"
    },
    {
      "r": "4.6.0",
      "os": "win",
      "version": "1.5.0",
      "date": "2026-05-11T19:27:00.000Z",
      "arch": "x86_64",
      "commit": "6f96c3ef5e8d09e99aec7ec01dd456a65fd060c3",
      "fileid": "6c166eea148f38e40b469f6cc75ffdb7b9cffbd3387c674a1dd2354a71d3ad1c",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/insightrx/actions/runs/25691947390"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "1.5.0",
      "date": "2026-05-22T11:15:46.000Z",
      "arch": "emscripten",
      "commit": "6f96c3ef5e8d09e99aec7ec01dd456a65fd060c3",
      "fileid": "e14d47445b93c46a7cf9151d6068c931eae3502280f801c34f00fd97ad7a62f1",
      "status": "success",
      "buildurl": "https://github.com/r-universe/insightrx/actions/runs/25691947390"
    }
  ]
}