{ "_id": "6a1ee695b401979e73411590", "Package": "clinPK", "Type": "Package", "Title": "Clinical Pharmacokinetics Toolkit", "Version": "0.14.0", "Date": "2024-02-22", "Authors@R": "c(person(\"Ron\", \"Keizer\", email = \"ron@insight-rx.com\", role\n= c(\"aut\", \"cre\")), person(\"Jasmine\", \"Hughes\", email =\n\"jasmine@insight-rx.com\", role = \"aut\"), person(\"Dominic\",\n\"Tong\", email = \"dominic@insight-rx.com\", role = \"aut\"),\nperson(\"Kara\", \"Woo\", email = \"kara@insight-rx.com\", role = c(\"aut\")),\nperson(\"Michael\", \"McCarthy\", email = \"michael.mccarthy@insight-rx.com\",\nrole = \"aut\"),\nperson(\"InsightRX\", role = c(\"cph\", \"fnd\")))", "Description": "Provides equations commonly used in clinical\npharmacokinetics and clinical pharmacology, such as equations\nfor dose individualization, compartmental pharmacokinetics,\ndrug exposure, anthropomorphic calculations, clinical\nchemistry, and conversion of common clinical parameters. Where\npossible and relevant, it provides multiple published and\npeer-reviewed equations within the respective R function.", "URL": "https://github.com/InsightRX/clinPK,\nhttps://insightrx.github.io/clinPK/", "License": "MIT + file LICENSE", "Encoding": "UTF-8", "Roxygen": "list(markdown = TRUE)", "RoxygenNote": "7.3.2", "Config/testthat/edition": "3", "LazyData": "true", "Repository": "https://insightrx.r-universe.dev", "Date/Publication": "2026-05-19 21:41:19 UTC", "RemoteUrl": "https://github.com/insightrx/clinpk", "RemoteRef": "HEAD", "RemoteSha": "c4392bac4d39f39f9fa6d9d3586d9ac6f6fd2263", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-19 22:28:04 UTC", "User": "root" }, "Author": "Ron Keizer [aut, cre],\nJasmine Hughes [aut],\nDominic Tong [aut],\nKara Woo [aut],\nMichael McCarthy [aut],\nInsightRX [cph, fnd]", "Maintainer": "Ron Keizer ", "MD5sum": "d597e997631b8d166ef5c9558a01596d", "_user": "insightrx", "_type": "src", "_file": "clinPK_0.14.0.tar.gz", "_fileid": "dc3a4640aa68dc027a00f376afa55760444e49cacb44fd957c496817ba4ae252", "_filesize": 502392, "_sha256": "dc3a4640aa68dc027a00f376afa55760444e49cacb44fd957c496817ba4ae252", "_created": "2026-05-19T22:28:04.000Z", "_published": "2026-06-02T14:20:05.418Z", "_distro": "noble", "_jobs": [ { "job": 79092711735, "time": 123, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "WARNING", "artifact": "7096930103" }, { "job": 79092711869, "time": 121, "config": "linux-release-x86_64", "r": "4.6.0", "check": "WARNING", "artifact": "7096929870" }, { "job": 79092711746, "time": 88, "config": "macos-oldrel-arm64", "r": "4.5.3", "check": "WARNING", "artifact": "7096920275" }, { "job": 79092711729, "time": 96, "config": "macos-release-arm64", "r": "4.6.0", "check": "WARNING", "artifact": "7096922580" }, { "job": 79092710717, "time": 190, "config": "source", "r": "4.6.0", "check": "OK", "artifact": "7096895229" }, { "job": 79092710874, "time": 92, "config": "wasm-release", "r": "4.6.0", "check": "OK", 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"roninsightrx", "description": "", "uuid": 15008273 }, "_registered": true, "_dependencies": [ { "package": "R", "version": ">= 2.10", "role": "Depends" }, { "package": "testthat", "version": ">= 3.0.0", "role": "Suggests" } ], "_owner": "insightrx", "_selfowned": true, "_usedby": 0, "_updates": [ { "week": "2025-23", "n": 1 }, { "week": "2025-31", "n": 1 }, { "week": "2025-42", "n": 1 }, { "week": "2026-20", "n": 1 }, { "week": "2026-21", "n": 1 } ], "_tags": [ { "name": "v1.73", "date": "2025-06-04" }, { "name": "v1.74", "date": "2025-06-04" }, { "name": "v1.75", "date": "2025-07-28" }, { "name": "v1.76", "date": "2025-07-28" }, { "name": "v1.77", "date": "2025-07-28" }, { "name": "v1.78", "date": "2025-10-15" }, { "name": "v1.79", "date": "2025-10-15" }, { "name": "v1.80", "date": "2025-10-15" }, { "name": "v1.81", "date": "2025-10-15" }, { "name": "v1.82", "date": "2025-10-15" }, { "name": "v1.83", "date": "2025-10-15" }, { "name": "v1.84", "date": "2025-10-15" }, { "name": "v1.85", "date": "2025-10-15" } ], "_topics": [ "clinical-research", "pharmacokinetics" ], "_stars": 32, "_contributors": [ { "user": "karawoo", "count": 164, "uuid": 4452678 }, { "user": "jasmineirx", "count": 135, "uuid": 43552465 }, { "user": "roninsightrx", "count": 114, "uuid": 15008273 }, { "user": "ronkeizer", "count": 57, "uuid": 243793 }, { "user": "mccarthy-m-g", "count": 39, "uuid": 51542091 }, { "user": "vikrammatange", "count": 33, "uuid": 31862085 }, { "user": "jordanbrooks33", "count": 15, "uuid": 129786148 }, { "user": "insightrx-ci", "count": 10, "uuid": 33671449 }, { "user": "perugolate", "count": 2, "uuid": 5621391 }, { "user": "dominic-irx", "count": 1, "uuid": 59584945 } ], "_userbio": { "uuid": 14945763, "type": "organization", "name": "InsightRX", "description": "Precision dosing and clinical analytics" }, "_downloads": { "count": 292, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/clinPK" }, "_devurl": "https://github.com/insightrx/clinpk", "_pkgdown": "https://insightrx.github.io/clinPK/", "_searchresults": 63, "_rbuild": "4.6.0", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/clinPK.html", "extra/contents.json", "extra/NEWS.html", "extra/NEWS.txt", "extra/readme.html", "extra/readme.md", "manual.pdf" ], "_homeurl": "https://github.com/insightrx/clinpk", "_realowner": "insightrx", "_cranurl": true, "_releases": [ { "version": "0.9.0", "date": "2017-06-19" }, { "version": "0.11.1", "date": "2022-05-09" }, { "version": "0.13.0", "date": "2024-02-24" } ], "_exports": [ "%<=%", "absolute2relative_bsa", "accumulation_ratio", "add_ruv", "auc2dose", "calc_abw", "calc_aki_stage", "calc_amts_for_conc", "calc_baseline_scr", "calc_bmi", "calc_bsa", "calc_carboplatin_calvert", "calc_cefepime_neurotoxicity", "calc_creat", "calc_creat_neo", "calc_dosing_weight", "calc_egfr", "calc_egfr_cystatin", "calc_ffm", "calc_ibw", "calc_kel_double_tdm", "calc_kel_single_tdm", "calc_kgfr", "calc_lbw", "calc_neutropenia_grade", "calc_t12", "calc_treosulfan_success", "check_covs_available", "cm2inch", "conc2mol", "convert_albumin_unit", "convert_bilirubin_unit", "convert_creat_assay", "convert_creat_unit", "convert_flow_unit", "dose2auc", "egfr_cov_reqs", "find_nearest_dose", "find_nearest_interval", "fraction_of_ss", "inch2cm", "kg2lbs", "kg2oz", "lbs2kg", "median_bmi_for_age", "median_height_for_age", "median_weight_for_age", "median_weight_for_height", "mol2conc", "nca", "oz2kg", "pct_bmi_for_age", "pct_height_for_age", "pct_weight_for_age", "pct_weight_for_height", "pk_1cmt_bolus", "pk_1cmt_bolus_cmax_ss", "pk_1cmt_bolus_cmin_ss", "pk_1cmt_bolus_dose_from_cmax", "pk_1cmt_bolus_dose_from_cmin", "pk_1cmt_bolus_ss", "pk_1cmt_inf", "pk_1cmt_inf_cmax_ss", "pk_1cmt_inf_cmin_ss", "pk_1cmt_inf_dose_for_range", "pk_1cmt_inf_dose_from_cmax", "pk_1cmt_inf_dose_from_cmin", "pk_1cmt_inf_ss", "pk_1cmt_oral", "pk_1cmt_t12", "pk_2cmt_bolus", "pk_2cmt_bolus_cmax_ss", "pk_2cmt_bolus_cmin_ss", "pk_2cmt_bolus_dose_from_cmax", "pk_2cmt_bolus_dose_from_cmin", "pk_2cmt_bolus_ss", "pk_2cmt_inf", "pk_2cmt_inf_cmax_ss", "pk_2cmt_inf_cmin_ss", "pk_2cmt_inf_dose_from_cmax", "pk_2cmt_inf_dose_from_cmin", "pk_2cmt_inf_ss", "pk_2cmt_t12", "pk_2cmt_t12_interval", "relative2absolute_bsa", "time_to_ss", "valid_units", "weight2kg" ], "_datasets": [ { "name": "bmi_for_age_children", "title": "CDC Growth Charts", "object": "bmi_for_age_children", "class": [ "data.frame" ], "fields": [ "sex", "age", "L", "M", "S", "P3", "P5", "P10", "P25", "P50", "P75", "P85", "P90", "P95", "P97" ], "rows": 438, "table": true, "tojson": true }, { "name": "height_for_age", "title": "CDC Growth Charts", "object": "height_for_age", "class": [ "data.frame" ], "fields": [ "sex", "age", "L", "M", "S", "P3", "P5", "P10", "P25", "P50", "P75", "P90", "P95", "P97" ], "rows": 484, "table": true, "tojson": true }, { "name": "weight_for_age", "title": "CDC Growth Charts", "object": "weight_for_age", "class": [ "data.frame" ], "fields": [ "sex", "age", "L", "M", "S", "P3", "P5", "P10", "P25", "P50", "P75", "P90", "P95", "P97" ], "rows": 484, "table": true, "tojson": true }, { "name": "weight_for_height_children", "title": "CDC Growth Charts", "object": "weight_for_height_children", "class": [ "data.frame" ], "fields": [ "sex", "height", "L", "M", "S", "P3", "P5", "P10", "P25", "P50", "P75", "P85", "P90", "P95", "P97" ], "rows": 92, "table": true, "tojson": true }, { "name": "weight_for_height_infants", "title": "CDC Growth Charts", "object": "weight_for_height_infants", "class": [ "data.frame" ], "fields": [ "sex", "height", "L", "M", "S", "P3", "P5", "P10", "P25", "P50", "P75", "P90", "P95", "P97" ], "rows": 120, "table": true, "tojson": true } ], "_help": [ { "page": "absolute2relative_bsa", "title": "Convert quantity expressed in absolute units relative to normalized BSA", "topics": [ "absolute2relative_bsa" ] }, { "page": "accumulation_ratio", "title": "Calculate accumulation ratio This is the ratio of drug concentration or AUC at steady state over concentrations after single dose", "topics": [ "accumulation_ratio" ] }, { "page": "add_ruv", "title": "Add residual variability to data", "topics": [ "add_ruv" ] }, { "page": "auc2dose", "title": "Convert AUCtau or AUCt to dose (for 1-compartment linear PK model)", "topics": [ "auc2dose" ] }, { "page": "calc_abw", "title": "Calculate adjusted body weight (ABW)", "topics": [ "calc_abw" ] }, { "page": "calc_aki_stage", "title": "Calculate AKI stage", "topics": [ "calc_aki_stage" ] }, { "page": "calc_amts_for_conc", "title": "Calculate the amounts in all compartments in a compartmental PK system based on a given concentration in the central compartment, and assuming steady state.", "topics": [ "calc_amts_for_conc" ] }, { "page": "calc_baseline_scr", "title": "Calculate baseline sCr", "topics": [ "calc_baseline_scr" ] }, { "page": "calc_bmi", "title": "Calculate BMI", "topics": [ "calc_bmi" ] }, { "page": "calc_bsa", "title": "Calculate body surface area", "topics": [ "calc_bsa" ] }, { "page": "calc_carboplatin_calvert", "title": "Calvert equation for carboplatin", "topics": [ "calc_carboplatin_calvert" ] }, { "page": "calc_cefepime_neurotoxicity", "title": "Calculate Cefepime-associated Neurotoxicity", "topics": [ "calc_cefepime_neurotoxicity" ] }, { "page": "calc_creat", "title": "Estimate serum creatinine", "topics": [ "calc_creat" ] }, { "page": "calc_creat_neo", "title": "Estimate serum creatinine in neonates", "topics": [ "calc_creat_neo" ] }, { "page": "calc_dosing_weight", "title": "Calculate commonly used \"dosing weight\"", "topics": [ "calc_dosing_weight" ] }, { "page": "calc_egfr", "title": "Calculate eGFR", "topics": [ "calc_egfr" ] }, { "page": "calc_egfr_cystatin", "title": "Calculate eGFR based on Cystatin C measurements", "topics": [ "calc_egfr_cystatin" ] }, { "page": "calc_ffm", "title": "Calculate fat-free mass", "topics": [ "calc_ffm" ] }, { "page": "calc_ibw", "title": "Calculate ideal body weight in kg for children and adults", "topics": [ "calc_ibw", "ibw_devine", "ibw_standard" ] }, { "page": "calc_kel_double_tdm", "title": "Calculate elimination rate when given two TDM samples", "topics": [ "calc_kel_double_tdm" ] }, { "page": "calc_kel_single_tdm", "title": "Calculate elimination rate when given a single TDM sample", "topics": [ "calc_kel_single_tdm" ] }, { "page": "calc_kgfr", "title": "Calculate kinetic GFR", "topics": [ "calc_kgfr" ] }, { "page": "calc_lbw", "title": "Calculate lean body weight", "topics": [ "calc_lbw" ] }, { "page": "calc_neutropenia_grade", "title": "Calculate neutropenia grade from ANC", "topics": [ "calc_neutropenia_grade" ] }, { "page": "calc_t12", "title": "Calculate half-life based on two points", "topics": [ "calc_t12" ] }, { "page": "calc_treosulfan_success", "title": "Calculate probability of therapeutic success for treosulfan", "topics": [ "calc_treosulfan_success" ] }, { "page": "check_covs_available", "title": "Checks whether required covariates for eGFR calculations are present", "topics": [ "check_covs_available" ] }, { "page": "cm2inch", "title": "Convert cm to inch", "topics": [ "cm2inch" ] }, { "page": "conc2mol", "title": "Convert concentration to molar", "topics": [ "conc2mol" ] }, { "page": "convert_albumin_unit", "title": "Convert albumin from / to units", "topics": [ "convert_albumin_unit" ] }, { "page": "convert_bilirubin_unit", "title": "Convert bilirubin from / to units", "topics": [ "convert_bilirubin_unit" ] }, { "page": "convert_creat_assay", "title": "Convert serum creatinine from various assays to Jaffe", "topics": [ "convert_creat_assay" ] }, { "page": "convert_creat_unit", "title": "Convert creatinine to different unit", "topics": [ "convert_creat_unit" ] }, { "page": "convert_flow_unit", "title": "Convert flow (e.g. clearance) from / to units", "topics": [ "convert_flow_unit" ] }, { "page": "dose2auc", "title": "Convert dose to expected AUCinf or AUCt for 1 compartment linear PK model", "topics": [ "dose2auc" ] }, { "page": "egfr_cov_reqs", "title": "Returns parameters needed to calculate eGFR according to the method specified.", "topics": [ "egfr_cov_reqs" ] }, { "page": "find_nearest_dose", "title": "Generic function to calculate the dose nearest to a specific dose unit increment", "topics": [ "find_nearest_dose" ] }, { "page": "find_nearest_interval", "title": "Generic function to calculate the interval nearest to a possible dosing interval", "topics": [ "find_nearest_interval" ] }, { "page": "fraction_of_ss", "title": "Calculate fraction of steady state at particular time after start of dosing", "topics": [ "fraction_of_ss" ] }, { "page": "growth-charts", "title": "CDC Growth Charts", "topics": [ "bmi_for_age_children", "bmi_for_age_children,", "growth-charts", "height_for_age", "height_for_age,", "weight_for_age", "weight_for_age,", "weight_for_height_children", "weight_for_height_infants", "weight_for_height_infants," ] }, { "page": "inch2cm", "title": "Convert inch to cm", "topics": [ "inch2cm" ] }, { "page": "kg2lbs", "title": "Convert kg to lbs", "topics": [ "kg2lbs" ] }, { "page": "kg2oz", "title": "Convert kg to oz", "topics": [ "kg2oz" ] }, { "page": "lbs2kg", "title": "Convert lbs to kg", "topics": [ "lbs2kg" ] }, { "page": "median_x_for_y", "title": "Median growth values for infants and children", "topics": [ "median_bmi_for_age", "median_height_for_age", "median_weight_for_age", "median_weight_for_height", "median_x_for_y" ] }, { "page": "mol2conc", "title": "Convert molar to concentration", "topics": [ "mol2conc" ] }, { "page": "nca", "title": "Perform an NCA based on a NONMEM-style dataset", "topics": [ "nca" ] }, { "page": "oz2kg", "title": "Convert oz to kg", "topics": [ "oz2kg" ] }, { "page": "pct_x_for_y", "title": "Growth percentiles for infants and children", "topics": [ "pct_bmi_for_age", "pct_height_for_age", "pct_weight_for_age", "pct_weight_for_height", "pct_x_for_y" ] }, { "page": "pk_1cmt_bolus", "title": "Concentration predictions for 1-compartmental PK model after single or multiple bolus doses", "topics": [ "pk_1cmt_bolus" ] }, { "page": "pk_1cmt_bolus_cmax_ss", "title": "Cmax for linear 1-compartment PK model at steady state, bolus dosing", "topics": [ "pk_1cmt_bolus_cmax_ss" ] }, { "page": "pk_1cmt_bolus_cmin_ss", "title": "Cmin (trough) for linear 1-compartment PK model at steady state, bolus dosing", "topics": [ "pk_1cmt_bolus_cmin_ss" ] }, { "page": "pk_1cmt_bolus_dose_from_cmax", "title": "Calculate dose to achieve steady state Cmax for 1-compartmental PK model bolus dosing at steady state", "topics": [ "pk_1cmt_bolus_dose_from_cmax" ] }, { "page": "pk_1cmt_bolus_dose_from_cmin", "title": "Calculate dose to achieve steady state trough for 1-compartmental PK model bolus dosing at steady state", "topics": [ "pk_1cmt_bolus_dose_from_cmin" ] }, { "page": "pk_1cmt_bolus_ss", "title": "Concentration predictions for 1-compartmental PK model with bolus dosing at steady state", "topics": [ "pk_1cmt_bolus_ss" ] }, { "page": "pk_1cmt_inf", "title": "Concentration predictions for 1-compartmental PK model after single or multiple bolus doses", "topics": [ "pk_1cmt_inf" ] }, { "page": "pk_1cmt_inf_cmax_ss", "title": "Cmax for linear 1-compartment PK model at steady state", "topics": [ "pk_1cmt_inf_cmax_ss" ] }, { "page": "pk_1cmt_inf_cmin_ss", "title": "Cmin (trough) for linear 1-compartment PK model at steady state", "topics": [ "pk_1cmt_inf_cmin_ss" ] }, { "page": "pk_1cmt_inf_dose_for_range", "title": "Calculate dose based on a given AUC24, Cmax, and Cmin, assuming 1-compartment model", "topics": [ "pk_1cmt_inf_dose_for_range" ] }, { "page": "pk_1cmt_inf_dose_from_cmax", "title": "Calculate dose to achieve steady state Cmax for 1-compartmental PK model with infusion dosing at steady state", "topics": [ "pk_1cmt_inf_dose_from_cmax" ] }, { "page": "pk_1cmt_inf_dose_from_cmin", "title": "Calculate dose to achieve steady state trough for 1-compartmental PK model with infusion dosing at steady state", "topics": [ "pk_1cmt_inf_dose_from_cmin" ] }, { "page": "pk_1cmt_inf_ss", "title": "Concentration predictions for 2-compartmental PK model with infusion dosing at steady state", "topics": [ "pk_1cmt_inf_ss" ] }, { "page": "pk_1cmt_oral", "title": "Concentration predictions for 1-compartmental oral PK model after single or multiple bolus doses", "topics": [ "pk_1cmt_oral" ] }, { "page": "pk_1cmt_t12", "title": "Calculate terminal half-life for 1-compartment model", "topics": [ "pk_1cmt_t12" ] }, { "page": "pk_2cmt_bolus", "title": "Concentration predictions for 2-compartmental PK model, single or multiple bolus doses", "topics": [ "pk_2cmt_bolus" ] }, { "page": "pk_2cmt_bolus_cmax_ss", "title": "Cmax for 2-compartmental PK model, bolus dosing at steady state", "topics": [ "pk_2cmt_bolus_cmax_ss" ] }, { "page": "pk_2cmt_bolus_cmin_ss", "title": "Cmin (trough) for 2-compartmental PK model, bolus dosing at steady state", "topics": [ "pk_2cmt_bolus_cmin_ss" ] }, { "page": "pk_2cmt_bolus_dose_from_cmax", "title": "Calculate dose to achieve steady state Cmax for 2-compartmental PK model bolus dosing at steady state", "topics": [ "pk_2cmt_bolus_dose_from_cmax" ] }, { "page": "pk_2cmt_bolus_dose_from_cmin", "title": "Calculate dose to achieve steady state trough for 2-compartmental PK model bolus dosing at steady state", "topics": [ "pk_2cmt_bolus_dose_from_cmin" ] }, { "page": "pk_2cmt_bolus_ss", "title": "Concentration predictions for 2-compartmental PK model, bolus dosing at steady state", "topics": [ "pk_2cmt_bolus_ss" ] }, { "page": "pk_2cmt_inf", "title": "Concentration predictions for 2-compartmental PK model, single or multiple infusions", "topics": [ "pk_2cmt_inf" ] }, { "page": "pk_2cmt_inf_cmax_ss", "title": "Cmax (trough) for 2-compartmental PK model, bolus dosing at steady state", "topics": [ "pk_2cmt_inf_cmax_ss" ] }, { "page": "pk_2cmt_inf_cmin_ss", "title": "Cmin (trough) for 2-compartmental PK model, bolus dosing at steady state", "topics": [ "pk_2cmt_inf_cmin_ss" ] }, { "page": "pk_2cmt_inf_dose_from_cmax", "title": "Calculate dose to achieve steady state Cmax for 2-compartmental PK model with infusion dosing at steady state", "topics": [ "pk_2cmt_inf_dose_from_cmax" ] }, { "page": "pk_2cmt_inf_dose_from_cmin", "title": "Calculate dose to achieve steady state trough for 2-compartmental PK model with infusion dosing at steady state", "topics": [ "pk_2cmt_inf_dose_from_cmin" ] }, { "page": "pk_2cmt_inf_ss", "title": "Concentration predictions for 2-compartmental PK model with infusion dosing at steady state", "topics": [ "pk_2cmt_inf_ss" ] }, { "page": "pk_2cmt_t12", "title": "Calculate half-life(s) for 2-compartment model", "topics": [ "pk_2cmt_t12" ] }, { "page": "pk_2cmt_t12_interval", "title": "Calculate average half-life for 2-compartment model during a specific interval", "topics": [ 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